Dou Lab

27. RNA m⁵C oxidation by TET2 regulates chromatin state and leukaemogenesis

Zhongyu Zou*, Xiaoyang Dou*, Ying Li*, Zijie Zhang, Juan Wang, Boyang Gao, Yu Xiao, Yiding Wang, Lijie Zhao, Chenxi Sun, Qinzhe Liu, Xianbin Yu, Hao Wang, Juyeong Hong, Qing Dai, Feng-Chun Yang, Mingjiang Xu, Chuan HeNature[link]

26. IGF2BP3 promotes mRNA degradation through internal m⁷G modification

Chang Liu*, Xiaoyang Dou*, Yutao Zhao*, Linda Zhang, Lisheng Zhang, Qing Dai, Jun Liu, Tong Wu, Yu Xiao, Chuan HeNature Communications[link]

25. Chemical manipulation of m¹A mediates its detection in human tRNA

Kinga Pajdzik*, Ruitu Lyu*, Xiaoyang Dou*, Chang Ye, Li-Sheng Zhang, Qing Dai, Chuan HeRNA[link]

24. Zebrafish Mbd5 binds to RNA m⁵C and regulates histone deubiquitylation and gene expression in development metabolism and behavior

Jianhua Guo, Zhongyu Zou, Xiaoyang Dou, Xiang Zhao, Yimin Wang, Liqiang Wei, Yan Pi, Yi Wang, Chuan He, Su GuoNucleic Acids Research[link]

23. KARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions

Tong Wu, Anthony Youzhi Cheng, Yuexiu Zhang, Jiayu Xu, Jinjun Wu, Li Wen, Xiao Li, Bei Liu, Xiaoyang Dou, Pingluan Wang, Linda Zhang, Jingyi Fei, Jianrong Li, Zhengqing Ouyang, Chuan HeNature Biotechnology[link]

22. Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing

Yu Xiao, Yan-Ming Chen, Zhongyu Zou, Chang Ye, Xiaoyang Dou, Jinjun Wu, Chang Liu, Shun Liu, Hao Yan, Pingluan Wang, Tie-Bo Zeng, Qinzhe Liu, Jingyi Fei, Weixin Tang, Chuan HeNature Methods[link]

21. Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m⁶A/YTHDF2 drives extrinsic radioresistance

Liangliang Wang, Wei Si, Xianbin Yu, Andras Piffko, Xiaoyang Dou, Xingchen Ding, Jason Bugno, Kaiting Yang, Chuangyu Wen, Linda Zhang, Dapeng Chen, Xiaona Huang, Jiaai Wang, Ainhoa Arina, Sean Pitroda, Steven J Chmura, Chuan He, Hua Laura Liang, Ralph WeichselbaumJournal of Clinical Investigation[link]

20. Dysregulation of the Epitranscriptomic Mark m¹A in Ischemic Stroke

Anil K Chokkalla, Kinga Pajdzik, Xiaoyang Dou, Qing Dai, Suresh L Mehta, Vijay Arruri, Raghu VemugantiTranslational Stroke Research[link]

19. METTL14 is a chromatin regulator independent of its RNA N⁶-methyladenosine methyltransferase activity

Xiaoyang Dou*, Lulu Huang*, Yu Xiao*, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun LiuProtein & Cell[link]

18. RBFOX2 recognizes N⁶-methyladenosine to suppress transcription and block myeloid leukaemia differentiation

Xiaoyang Dou*, Yu Xiao*, Chao Shen*, Kitty Wang*, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen, Jianjun Chen, Chuan HeNature Cell Biology[link]

17. Globally reduced N⁶-methyladenosine (m⁶A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

Yini Li*, Xiaoyang Dou*, Jun Liu*, Yu Xiao, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W Ostrow, Chuan He, Shuying SunNature Neuroscience[link]

16. YTHDF2/m⁶A/NF‐κB axis controls anti‐tumor immunity by regulating intratumoral Tregs

Linda Zhang, Xiaoyang Dou, Zhong Zheng, Chang Ye, Thomas X Lu, Hua L Liang, Liangliang Wang, Ralph R Weichselbaum, Chuan HeThe EMBO Journal[link]

15. YTHDF2 inhibition potentiates radiotherapy antitumor efficacy

Liangliang Wang*, Xiaoyang Dou*, Shijie Chen*, Xianbin Yu, Xiaona Huang, Linda Zhang, Yantao Chen, Jiaai Wang, Kaiting Yang, Jason Bugno, Sean Pitroda, Xingchen Ding, Andras Piffko, Wei Si, Chao Chen, Hualiang Jiang, Bing Zhou, Steven J Chmura, Cheng Luo, Hua Laura Liang, Chuan He, Ralph R WeichselbaumCancer Cell[link]

14. Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution

Qing Dai, Li-Sheng Zhang, Hui-Lung Sun, Kinga Pajdzik, Lei Yang, Chang Ye, Cheng-Wei Ju, Shun Liu, Yuru Wang, Zhong Zheng, Linda Zhang, Bryan T Harada, Xiaoyang Dou, Iryna Irkliyenko, Xinran Feng, Wen Zhang, Tao Pan, Chuan HeNature Biotechnology[link]

13. Exon architecture controls mRNA m⁶A suppression and gene expression

P Cody He*, Jiangbo Wei*, Xiaoyang Dou*, Bryan T Harada*, Zijie Zhang, Ruiqi Ge, Chang Liu, Li-Sheng Zhang, Xianbin Yu, Shuai Wang, Ruitu Lyu, Zhongyu Zou, Mengjie Chen, Chuan HeScience[link]

12. Nuclear m⁶A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

Chuan Chen, Wenqiang Liu, Guo Jiayin, Yuanyuan Liu, Xuelian Liu, Jun Liu, Dou Xiaoyang, Le Rongrong, Yixin Huang, Chong Li, Yang Lingyue, Kou Xiaochen, Yanhong Zhao, You Wu, Jiayu Chen, Hong Wang, Bin Shen, Gao Yawei, Gao ShaorongProtein & Cell[link]

11. FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development

Jiangbo Wei, Xianbin Yu, Lei Yang, Xuelian Liu, Boyang Gao, Boxian Huang, Xiaoyang Dou, Jun Liu, Zhongyu Zou, Xiao-Long Cui, Li-Sheng Zhang, Xingsen Zhao, Qinzhe Liu, P Cody He, Caraline Sepich-Poore, Nicole Zhong, Wenqiang Liu, Yanhe Li, Xiaochen Kou, Yanhong Zhao, You Wu, Xuejun Cheng, Chuan Chen, Yiming An, Xueyang Dong, Huanyu Wang, Qiang Shu, Ziyang Hao, Tao Duan, Yu-Ying He, Xuekun Li, Shaorong Gao, Yawei Gao, Chuan HeScience[link]

10. N⁶-deoxyadenosine methylation in mammalian mitochondrial DNA

Ziyang Hao, Tong Wu, Xiaolong Cui, Pingping Zhu, Caiping Tan, Xiaoyang Dou, Kai-Wen Hsu, Yueh-Te Lin, Pei-Hua Peng, Li-Sheng Zhang, Yawei Gao, Lulu Hu, Hui-Lung Sun, Allen Zhu, Jianzhao Liu, Kou-Juey Wu, Chuan HeMolecular Cell[link]

9. DNA 5-methylcytosine-specific amplification and sequencing

Chang Liu, Xiaolong Cui, Boxuan Simen Zhao, Pradnya Narkhede, Yawei Gao, Jun Liu, Xiaoyang Dou, Qing Dai, Li-Sheng Zhang, Chuan HeJournal of the American Chemical Society[link]

8.N⁶-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Jun Liu*, Xiaoyang Dou*, Chuanyuan Chen*, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao, Dali Han, Chuan HeScience[link]

7. The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A

Xiaoyang Dou*, Jerome D Boyd-Kirkup*, Joseph McDermott*, Xiaoli Zhang*, Fang Li, Bowen Rong, Rui Zhang, Bisi Miao, Peilin Chen, Hao Cheng, Jianhuang Xue, David Bennett, Jiemin Wong, Fei Lan, Jing-Dong J HanGenome Research[link]

6. Impact of dietary interventions on noncoding RNA networks and mRNAs encoding chromatin-related factors

Christopher D Green*, Yi Huang*, Xiaoyang Dou*, Liu Yang, Yong Liu, Jing-Dong J HanCell Reports[link]

5. Understanding super-enhancers

Hao Cheng*, Xiaoyang Dou*, J Han Jing-dongScience China. Life Sciences[link]

4. Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation

Pingyu Liu, Xiaoyang Dou, Guangdun Peng, Jing-Dong Jackie Han, Naihe JingGenomics Data[link]

3. Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate

Pingyu Liu, Xiaoyang Dou, Chang Liu, Lingbo Wang, Can Xing, Guangdun Peng, Jun Chen, Fang Yu, Yunbo Qiao, Lu Song, Yuxuan Wu, Chunmei Yue, Jinsong Li, Jing-Dong J Han, Ke Tang, Naihe JingNature Communications[link]

2. Integrative Epigenomics

Ming Su*, Xiaoyang Dou*, Hao Cheng*, Jing-Dong J HanComputational and Statistical Epigenomics[link]

1. Integrating genomic, epigenomic, and transcriptomic features reveals modular signatures underlying poor prognosis in ovarian cancer

Wei Zhang, Yi Liu, Na Sun, Dan Wang, Jerome Boyd-Kirkup, Xiaoyang Dou, Jing-Dong Jackie HanCell Reports[link]